Wen Yi Metabolism Phosphofructokinase 1 Glycosylation Regulates Cell Growth
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منابع مشابه
Phosphofructokinase 1 glycosylation regulates cell growth and metabolism.
Cancer cells must satisfy the metabolic demands of rapid cell growth within a continually changing microenvironment. We demonstrated that the dynamic posttranslational modification of proteins by O-linked β-N-acetylglucosamine (O-GlcNAcylation) is a key metabolic regulator of glucose metabolism. O-GlcNAcylation was induced at serine 529 of phosphofructokinase 1 (PFK1) in response to hypoxia. Gl...
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تاریخ انتشار 2012